![]() In the present study, the researchers tried to inhibit the inflammatory substances using therapeutic EVs that express on their membranes the receptors that bind to IL 6 and TNF-α. ![]() This knowledge has resulted in the development of biological drugs that dampen the inflammatory response by inhibiting TNF-α and IL 6. TNF-α and IL 6 form in the body under inflammatory conditions such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), and play a key part in inflammation and the subsequent tissue damage. Using biomolecular techniques, researchers at Karolinska Institutet have coated the outer EV membrane with therapeutic proteins, more precisely receptors that bind to the inflammatory substances TNF-α and interleukin 6 (IL 6). Consequently, EVs have garnered growing interest as potential drugs. The tiny bubbles are found naturally in bodily fluids, are able to pass through biological barriers, like the blood-brain barrier, and can be used as natural carriers of therapeutic substances. They are nanometre-sized membrane-coated packages excreted by cells that can deliver fatty acids, proteins and genetic material to different tissues. Extracellular vesicles (EVs) are important in inter-cellular communication as carriers of biological signals. ![]()
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